Fatigue characteristics of pulsed MIG-welded Al-Zn-Mg alloy

Pulse-current MIG welding of Al-Zn-Mg alloy was carried out using an extruded section of base material and Al-Mg (5183) filler wire. During welding the pulse parameters such as the mean current and pulse frequency were varied and their effect on the geometry and porosity content of weld deposit as well as the fatigue life of the weldment was studied. The pulse parameters were found to affect significantly the geometry and porosity content of weld deposit and consequently the fatigue life of the weldment. For a comparative study, weldments were also prepared by using conventional continuous current MIG-welding process, where welding currents equivalent to the mean currents of pulsed process were used. The fatigue life of the weldment was correlated with the geometry and porosity content of weld deposit.     

Turbulent natural convection heat transfer from a vertical plate to the power-law fluid at high prandtl numbers

A simple analytical technique for turbulent natural convection heat transfer from an isothermal vertical plate to a power-law fluid is developed. The model is based on the assumption that the turbulent heat transfer rate is controlled by the flow characteristic near the surface in the limit of large Prandtl numbers. The formulation proposed in this work agrees well with the correlations available in the literature.     

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, the substrate L-arginine (L-Arg), or product analog thiocitrulline reveal how dimerization, cofactor tetrahydrobiopterin, and L-Arg binding complete the catalytic center for synthesis of the essential biological signal and cytotoxin nitric oxide. Pterin binding refolds the central interface region, recruits new structural elements, creates a 30 angstrom deep active-center channel, and causes a 35 degrees helical tilt to expose a heme edge and the adjacent residue tryptophan-366 for likely reductase domain interactions and caveolin inhibition. Heme propionate interactions with pterin and L-Arg suggest that pterin has electronic influences on heme-bound oxygen. L-Arginine binds to glutamic acid-371 and stacks with heme in an otherwise hydrophobic pocket to aid activation of heme-bound oxygen by direct proton donation and thereby differentiate the two chemical steps of nitric oxide synthesis.     

Dicaf: a distributed architecture for intelligent transportation

The solution to increasing traffic congestion is not to simply build new roads. Instead, researchers hope to use technology to make more efficient use of the highway network that already exists. Key efforts to date have fallen into two categories. One set of studies has looked at the use of a centralized traffic management center that collects traffic congestion information at a single point and relays it to on-board computers in vehicles or directly to the drivers. Another set of studies has looked at systems that would prescribe the routes for vehicles. The authors describe their Dicaf (distributed scalable architecture for IVHS using a continuous-function congestion measure) system, which envisions a network of distributed, independent traffic management centers that provide congestion and other information to on-board navigation systems in the automobiles themselves. The navigation system uses that information to help drivers avoid slower traffic and thus find the fastest route home or anywhere     

DARYN-a distributed decision-making algorithm for railway networks:modeling and simulation

The state of the art in scheduling “point-to-point” trains in a railway network utilizes the principles of centralized decision-making. The major difficulty of this approach is that the execution time and the memory requirements increase nonlinearly as the system grows in size. The present paper introduces a new approach, “DARYN”, wherein the overall decision process is analyzed and distributed onto every natural entity of the system. In DARYN, the decision process for every train is executed by an on-board processor that negotiates, dynamically and progressively, for temporary ownership of the tracks with the respective station controlling the tracks, through explicit processor to processor communication primitives. This processor then computes its own route utilizing the results of its negotiation, its knowledge of the track layout of the entire system, and its evaluation of the cost function. Every station's decision process is also executed by a dedicated processor that, in addition, maintains absolute control over a given set of tracks and participates in the negotiation with the trains. Presently, DARYN utilizes a simple cost function. However, if one chooses to increase the complexity of the cost function, DARYN's advantage over the traditional approach increases due to its enormous available computational power. Given that the current microprocessors such as MC68030, MC88000, Intel 486, and Intel 860 are powerful yet relatively inexpensive, a network of concurrently executing processors may offer superior price-performance quotient over a single high performance computer     

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy

BACKGROUND: Bluetongue virus (BTV), which belongs to the Reoviridae family and orbivirus genus, is a non-enveloped, icosahedral, double-stranded RNA virus. Several protein layers enclose its genome; upon cell entry the outer layer is stripped away leaving a core, the surface of which is composed of VP7. The structure of the trimeric VP7 molecule has previously been determined using X-ray crystallography. The articulated VP7 subunit consists of two domains, one which is largely alpha-helical and the other, smaller domain, is a beta barrel with jelly-roll topology. The relative orientations of these two domains vary in different crystal forms. The structure of VP7 and the organizations of 780 subunits of this molecule in the core of virus is central to the assembly and function of BTV. RESULTS: A 23 A resolution map of the core, determined using electron cryomicroscopy (cryoEM) data, reveals that the 260 trimers of VP7 are organized on a rather precise T = 13 laevo icosahedral lattice, in accordance with the theory of quasi-equivalence. The VP7 layer occupies a shell that is between 260 A and 345 A from the centre of the core. Below this radius (230-260 A) lies the T = 1 layer of 120 molecules of VP3. By fitting the X-ray structure of an individual VP7 trimer onto the cryoEM BTV core structure, we have generated an atomic model of the VP7 layer of BTV. This demonstrates that one of the molecular structures seen in crystals of the isolated VP7 corresponds to the in vivo conformation of the molecule in the core. CONCLUSIONS: The beta-barrel domains of VP7 are external to the core and interact with protein in the outer layer of the mature virion. The lower, alpha-helical domains of VP7 interact with VP3 molecules which form the inner layer of the BTV core. Adjacent VP7 trimer-trimer interactions in the T = 13 layer are mediated principally through well-defined regions in the broader lower domains, to form a structure that conforms well with that expected from the theory of quasi-equivalence with no significant conformational changes within the individual trimers. The VP3 layer determines the particle size and forms a rather smooth surface upon which the two-dimensional lattice of VP7 trimers is laid down.     

Absolute stability of an implicit method based on third-order off-step discretization for the initial-value problem on a graded mesh

Engineering with Computers - We studied a new implicit method of order three based on two off-step points for the numerical solution of second-order nonlinear initial-value problems...